Microbial-generated amyloids and Alzheimer's disease (AD)
نویسندگان
چکیده
James M. Hill 1,2,3,4 and Walter J. Lukiw* 1 Louisiana State University Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA 2 Departments of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA 3 Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA 4 Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA, USA 5 Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, USA *Correspondence: [email protected]
منابع مشابه
Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer’s Disease (AD)
Since the inception of the human microbiome project (HMP) by the US National Institutes of Health (NIH) in 2007 there has been a keen resurgence in our recognition of the human microbiome and its contribution to development, immunity, neurophysiology, metabolic and nutritive support to central nervous system (CNS) health and disease. What is not generally appreciated is that (i) the ~1014 micro...
متن کاملMicrobiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).
According to the 'amyloid cascade hypothesis of Alzheimer's disease' first proposed about 16 years ago, the accumulation of Aβ peptides in the human central nervous system (CNS) is the primary influence driving Alzheimer's disease (AD) pathogenesis, and Aβ peptide accretion is the result of an imbalance between Aβ peptide production and clearance. In the last 18 months multiple laboratories hav...
متن کاملP115: A Novel High Tech Approach to Monitor the Pharmacotherapy of Alzheimer; a Narrative Review
Alzheimer's disease (AD) is multisystem and multifactor disease with a long no-symptom stage. We propose that a more effective approach to use fMRI as a still emerging, repeatable, non- invasive neuroimaging tools that can be very useful for evaluating, diagnosis, treatment and drugs- development. We studied 30 articles which published between 2008-2017 that included the effects of different bi...
متن کاملP137: Stem Cell Therapy in Alzheimer’s Disease
Alzheimer disease (AD) is a progressive neurodegenerative brain disorder which plays an important role in neural cell destruction and as a result it causes memory loss in the patients. This disease is also the most common type of dementia which doesn’t completely respond to medical treatments so no certain cure is available. Recent studies show the advantages of using stem cells (SCs) in ...
متن کاملExploiting amyloid: how and why bacteria use cross-β fibrils.
Many bacteria produce protein fibrils that are structurally analogous to those associated with protein misfolding diseases such as Alzheimer's disease. However, unlike fibrils associated with disease, bacterial amyloids have beneficial functions including conferring stability to biofilms, regulating development or imparting virulence. In the present review, we consider what makes amyloid fibril...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2015